Synergistic targeting of FLT3 mutations in AML via combined menin-MLL and FLT3 inhibition

The interaction of menin (MEN1) and MLL (MLL1, KMT2A) is a dependency and provides a potential opportunity for treatment of NPM1-mutant (NPM1(mut)) and MLL-rearranged (MLL-r) leukemias. Concomitant activating driver mutations in the gene encoding the tyrosine kinase FLT3 occur in both leukemias and...

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Udgivet i:Blood
Main Authors: Dzama, Margarita M., Steiner, Marlene, Rausch, Johanna, Sasca, Daniel, Schönfeld, Jonas, Kunz, Kerstin, Taubert, Martha C., McGeehan, Gerard M., Chen, Chun-Wei, Mupo, Annalisa, Hähnel, Patricia, Theobald, Matthias, Kindler, Thomas, Koche, Richard P., Vassiliou, George S., Armstrong, Scott A., Kühn, Michael W. M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2020
Fag:
Myeloid Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8215191/
https://ncbi.nlm.nih.gov/pubmed/32589720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020005037
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