Combinatorial treatment with menin and FLT3 inhibitors induces complete remission in AML models with activating FLT3 mutations

Lignende værker

• Theoretical models of inhibitory activity for inhibitors of protein–protein interactions: targeting menin–mixed lineage leukemia with small molecules
  af: Jedwabny, Wiktoria, et al.
  Udgivet: (2017)
• Menin-MLL inhibitors block oncogenic transformation by MLL fusion proteins in a fusion partner independent manner
  af: He, Shihan, et al.
  Udgivet: (2015)
• The complexity of blocking bivalent protein-protein interactions: development of a highly potent inhibitor of the menin-Mixed Lineage Leukemia (MLL) interaction
  af: Borkin, Dmitry, et al.
  Udgivet: (2018)
• Pharmacologic inhibition of the menin-MLL interaction leads to transcriptional repression of PEG10 and blocks hepatocellular carcinoma
  af: Kempinska, Katarzyna, et al.
  Udgivet: (2017)
• Synergistic targeting of FLT3 mutations in AML via combined menin-MLL and FLT3 inhibition
  af: Dzama, Margarita M., et al.
  Udgivet: (2020)