Intra-Vκ Cluster Recombination Shapes the Ig Kappa Locus Repertoire

During V(D)J recombination, RAG proteins introduce DNA double-strand breaks (DSBs) at recombination signal sequences (RSSs) that contain either 12- or 23-nt spacer regions. Coordinated 12/23 cleavage predicts that DSBs at variable (V) gene segments should equal the level of breakage at joining (J) s...

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Détails bibliographiques
Publié dans:Cell Rep
Auteurs principaux: Shinoda, Kenta, Maman, Yaakov, Canela, Andres, Schatz, David G., Livak, Ferenc, Nussenzweig, André
Format: Artigo
Langue:Inglês
Publié: 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8214342/
https://ncbi.nlm.nih.gov/pubmed/31875554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.11.088
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