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Intra-Vκ Cluster Recombination Shapes the Ig Kappa Locus Repertoire
During V(D)J recombination, RAG proteins introduce DNA double-strand breaks (DSBs) at recombination signal sequences (RSSs) that contain either 12- or 23-nt spacer regions. Coordinated 12/23 cleavage predicts that DSBs at variable (V) gene segments should equal the level of breakage at joining (J) s...
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| Veröffentlicht in: | Cell Rep |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8214342/ https://ncbi.nlm.nih.gov/pubmed/31875554 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.11.088 |
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