Biliary excretion of excess iron in mice requires hepatocyte iron import by Slc39a14

Iron is essential for erythropoiesis and other biological processes, but is toxic in excess. Dietary absorption of iron is a highly regulated process and is a major determinant of body iron levels. Iron excretion, however, is considered a passive, unregulated process, and the underlying pathways are...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Prajapati, Milankumar, Conboy, Heather L., Hojyo, Shintaro, Fukada, Toshiyuki, Budnik, Bogdan, Bartnikas, Thomas B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2021
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8214222/
https://ncbi.nlm.nih.gov/pubmed/34051234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100835
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