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Characterization of in vitro models of SLC30A10 deficiency

Manganese (Mn), an essential metal, can be toxic at elevated levels. In 2012, the first inherited cause of Mn excess was reported in patients with mutations in SLC30A10, a Mn efflux transporter. To explore the function of SLC30A10 in vitro, the current study used CRISPR/Cas9 gene editing to develop...

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Detalhes bibliográficos
Publicado no:Biometals
Main Authors: Prajapati, Milankumar, Pettiglio, Michael A., Conboy, Heather L., Mercadante, Courtney J., Hojyo, Shintaro, Fukada, Toshiyuki, Bartnikas, Thomas B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8204349/
https://ncbi.nlm.nih.gov/pubmed/33713241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10534-021-00296-y
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