SMARCB1 deletion in atypical teratoid rhabdoid tumors results in human endogenous retrovirus K (HML-2) expression

Atypical Teratoid Rhabdoid Tumor (AT/RT) is a rare pediatric central nervous system cancer often characterized by deletion or mutation of SMARCB1, a tumor suppressor gene. In this study, we found that SMARCB1 regulates Human Endogenous Retrovirus K (HERV-K, subtype HML-2) expression. HML-2 is a repe...

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Publicado no:Sci Rep
Main Authors: Doucet-O’Hare, Tara T., DiSanza, Brianna L., DeMarino, Catherine, Atkinson, Abigail L., Rosenblum, Jared S., Henderson, Lisa J., Johnson, Kory R., Kowalak, Jeffrey, Garcia-Montojo, Marta, Allen, Sariah J., Orr, Brent A., Santi, Mariarita, Wang, Tongguang, Fathi, Saeed, Lee, Myoung Hwa, Sampson, Kevon, Li, Wenxue, Zhuang, Zhengping, Nath, Avindra
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8213802/
https://ncbi.nlm.nih.gov/pubmed/34145313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-92223-x
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