Targeting Polo-like kinase 1 in SMARCB1 deleted atypical teratoid rhabdoid tumor

Atypical teratoid rhabdoid tumor (ATRT) is an aggressive and malignant pediatric brain tumor. Polo-like kinase 1 (PLK1) is highly expressed in many cancers and essential for mitosis. Overexpression of PLK1 promotes chromosome instability and aneuploidy by overriding the G2-M DNA damage and spindle c...

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Udgivet i:Oncotarget
Main Authors: Alimova, Irina, Pierce, Angela M., Harris, Peter, Donson, Andrew, Birks, Diane K., Prince, Eric, Balakrishnan, Ilango, Foreman, Nicholas K., Kool, Marcel, Hoffman, Lindsey, Venkataraman, Sujatha, Vibhakar, Rajeev
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5722562/
https://ncbi.nlm.nih.gov/pubmed/29228610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21932
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