Simultaneous Brg1 Knockout and MYCN Overexpression in Cerebellar Granule Neuron Precursors Is Insufficient to Drive Tumor Formation but Temporarily Enhances their Proliferation and Delays their Migration

Medulloblastoma (MB) is the most common malignant brain tumor in childhood. According to the World Health Organization (WHO) classification of central nervous system (CNS) tumors, this embryonal tumor is divided into a wingless (WNT)-activated, Sonic hedgehog (SHH)-activated, and non-WNT/non-SHH ent...

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Vydáno v:Cerebellum
Hlavní autoři: Holdhof, Dörthe, On, Ji Hoon, Schoof, Melanie, Göbel, Carolin, Schüller, Ulrich
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer US 2021
Témata:
Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8213679/
https://ncbi.nlm.nih.gov/pubmed/33387268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12311-020-01219-2
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