Simultaneous Brg1 Knockout and MYCN Overexpression in Cerebellar Granule Neuron Precursors Is Insufficient to Drive Tumor Formation but Temporarily Enhances their Proliferation and Delays their Migration

Medulloblastoma (MB) is the most common malignant brain tumor in childhood. According to the World Health Organization (WHO) classification of central nervous system (CNS) tumors, this embryonal tumor is divided into a wingless (WNT)-activated, Sonic hedgehog (SHH)-activated, and non-WNT/non-SHH ent...

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Bibliographic Details
Published in:Cerebellum
Main Authors: Holdhof, Dörthe, On, Ji Hoon, Schoof, Melanie, Göbel, Carolin, Schüller, Ulrich
Format: Artigo
Language:Inglês
Published: Springer US 2021
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8213679/
https://ncbi.nlm.nih.gov/pubmed/33387268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12311-020-01219-2
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