Simultaneous Brg1 Knockout and MYCN Overexpression in Cerebellar Granule Neuron Precursors Is Insufficient to Drive Tumor Formation but Temporarily Enhances their Proliferation and Delays their Migration

Medulloblastoma (MB) is the most common malignant brain tumor in childhood. According to the World Health Organization (WHO) classification of central nervous system (CNS) tumors, this embryonal tumor is divided into a wingless (WNT)-activated, Sonic hedgehog (SHH)-activated, and non-WNT/non-SHH ent...

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Detalhes bibliográficos
Publicado no:Cerebellum
Main Authors: Holdhof, Dörthe, On, Ji Hoon, Schoof, Melanie, Göbel, Carolin, Schüller, Ulrich
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2021
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8213679/
https://ncbi.nlm.nih.gov/pubmed/33387268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12311-020-01219-2
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