Caspase-1-Inhibitor AC-YVAD-CMK Inhibits Pyroptosis and Ameliorates Acute Kidney Injury in a Model of Sepsis

OBJECTIVE: To observe the protective effect of AC-YVAD-CMK on sepsis-induced acute kidney injury in mice and to explore its possible mechanisms primarily. METHODS: Eighteen male C57BL/6 mice were randomly divided into sham-operated group (Control), cecal ligation and puncture group (CLP), and CLP mo...

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Detalhes bibliográficos
Publicado no:Biomed Res Int
Main Authors: Yang, Mei, Fang, Jin-tao, Zhang, Ni-shang, Qin, Long-jiang, Zhuang, Yang-yang, Wang, Wei-wei, Zhu, Hai-ping, Zhang, Yan-jie, Xia, Peng, Zhang, Yan
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2021
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8213477/
https://ncbi.nlm.nih.gov/pubmed/34222479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2021/6636621
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