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The caspase-1 inhibitor AC-YVAD-CMK attenuates acute gastric injury in mice: involvement of silencing NLRP3 inflammasome activities

This study evaluated the protective effects of inhibiting caspase-1 activity or gastric acid secretion on acute gastric injury in mice. AC-YVAD-CMK, omeprazole, or vehicle were administered to mice before cold-restraint stress- or ethanol-induced gastric injury. Survival rates and histological evide...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Zhang, Fang, Wang, Liang, Wang, Jun-jie, Luo, Peng-fei, Wang, Xing-tong, Xia, Zhao-fan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4823746/
https://ncbi.nlm.nih.gov/pubmed/27053298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep24166
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