Caspase-1-inhibitor ac-YVAD-cmk reduces LPS-lethality in rats without affecting haematology or cytokine responses

The effect of acetyl–tyrosyl-valyl-alanyl-aspartyl–chloromethylketone (ac-YVAD-cmk), an irreversible caspase-1 (IL-1β converting enzyme, ICE) inhibitor on mortality, leukocyte and platelet counts and cytokine levels was investigated in a double-blind rat model of endotoxaemia. Intravenous (i.v.) bol...

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Detalhes bibliográficos
Main Authors: Mathiak, Guenther, Grass, Guido, Herzmann, Thomas, Luebke, Thomas, Zetina, Cecilia Cu, Boehm, Sebastian A, Bohlen, Heribert, Neville, Lewis F, Hoelscher, Arnulf H
Formato: Artigo
Idioma:Inglês
Publicado em: 2000
Assuntos:
Special Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572369/
https://ncbi.nlm.nih.gov/pubmed/11015286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703629
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