Vpr counteracts the restriction of LAPTM5 to promote HIV-1 infection in macrophages

The HIV-1 accessory proteins Vif, Vpu, and Nef can promote infection by overcoming the inhibitory effects of the host cell restriction factors APOBEC3G, Tetherin, and SERINC5, respectively. However, how the HIV-1 accessory protein Vpr enhances infection in macrophages but not in CD4(+) T cells remai...

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Foilsithe in:Nat Commun
Main Authors: Zhao, Li, Wang, Shumei, Xu, Meng, He, Yang, Zhang, Xiaowei, Xiong, Ying, Sun, Hong, Ding, Haibo, Geng, Wenqing, Shang, Hong, Liang, Guoxin
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2021
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8211709/
https://ncbi.nlm.nih.gov/pubmed/34140527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24087-8
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