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Acyl Donor Stringency and Dehydroaminoacyl Intermediates in β-Lactam Formation by a Non-Ribosomal Peptide Synthetase
Condensation (C) domains in non-ribosomal peptide synthetases catalyze peptide elongation steps whereby activated amino acid or peptidyl acyl donors are coupled with specific amino acid acceptors. In the biosynthesis of the β-lactam antibiotic nocardicin A, an unusual C domain converts a seryl tetra...
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| Publicat a: | ACS Chem Biol |
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| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2021
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8211430/ https://ncbi.nlm.nih.gov/pubmed/33847484 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.1c00117 |
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