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Spike-in normalization for single-cell RNA-seq reveals dynamic global transcriptional activity mediating anticancer drug response

The transcriptional plasticity of cancer cells promotes intercellular heterogeneity in response to anticancer drugs and facilitates the generation of subpopulation surviving cells. Characterizing single-cell transcriptional heterogeneity after drug treatments can provide mechanistic insights into dr...

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Detalhes bibliográficos
Publicado no:NAR Genom Bioinform
Main Authors: Wang, Xin, Frederick, Jane, Wang, Hongbin, Hui, Sheng, Backman, Vadim, Ji, Zhe
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8210883/
https://ncbi.nlm.nih.gov/pubmed/34159316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nargab/lqab054
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