Suppression of Microgliosis With the Colony-Stimulating Factor 1 Receptor Inhibitor PLX3397 Does Not Attenuate Memory Defects During Epileptogenesis in the Rat

Events of status epilepticus (SE) trigger the development of temporal lobe epilepsy (TLE), a type of focal epilepsy that is commonly drug-resistant and is highly comorbid with cognitive deficits. While SE-induced hippocampal injury, accompanied by gliosis and neuronal loss, typically disrupts cognit...

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Detalhes bibliográficos
Publicado no:Front Neurol
Main Authors: Wyatt-Johnson, Season K., Sommer, Alexandra L., Shim, Kevin Y., Brewster, Amy L.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Neurology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8209304/
https://ncbi.nlm.nih.gov/pubmed/34149593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fneur.2021.651096
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