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PLX3397 inhibits the accumulation of intra-tumoral macrophages and improves BET inhibitor efficacy in melanoma
Bromodomain and extra terminal inhibitors (BETi) delay tumor growth, in part, through tumor cell intrinsic alterations and initiation of anti-tumor CD8+ T cell responses. By contrast, BETi effects on pro-tumoral immune responses remain unclear. Here, we show that the next generation BETi, PLX51107,...
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| Publicado en: | Pigment Cell Melanoma Res |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7028511/ https://ncbi.nlm.nih.gov/pubmed/31696640 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/pcmr.12845 |
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