Inhibition of Colony-Stimulating Factor 1 Receptor by PLX3397 Prevents Amyloid Beta Pathology and Rescues Dopaminergic Signaling in Aging 5xFAD Mice

Alzheimer’s disease (AD) is a progressive neurodegenerative disease. In this study, to investigate the effect of microglial elimination on AD progression, we administered PLX3397, a selective colony-stimulating factor 1 receptor inhibitor, to the mouse model of AD (5xFAD mice). Amyloid-beta (Aβ) dep...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Son, Yeonghoon, Jeong, Ye Ji, Shin, Na-Rae, Oh, Se Jong, Nam, Kyung Rok, Choi, Hyung-Do, Choi, Jae Yong, Lee, Hae-June
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7432084/
https://ncbi.nlm.nih.gov/pubmed/32756440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21155553
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