Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer’s disease

BACKGROUND: Besides the two main classical features of amyloid beta aggregation and tau-containing neurofibrillary tangle deposition, neuroinflammation plays an important yet unclear role in the pathophysiology of Alzheimer’s disease (AD). Microglia are believed to be key mediators of neuroinflammat...

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Detalhes bibliográficos
Publicado no:Mol Neurodegener
Main Authors: Sosna, Justyna, Philipp, Stephan, Albay, Ricardo, Reyes-Ruiz, Jorge Mauricio, Baglietto-Vargas, David, LaFerla, Frank M., Glabe, Charles G.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5831225/
https://ncbi.nlm.nih.gov/pubmed/29490706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-018-0244-x
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