Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study

BACKGROUND: The colony stimulating factor 1 receptor (CSF1R) ligands, CSF1 and interleukin-34, and the KIT ligand, stem cell factor, are expressed in glioblastoma (GB). Microglia, macrophages, blood vessels, and tumor cells also express CSF1R, and depletion of the microglia reduces tumor burden and...

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Detalles Bibliográficos
Publicado en:Neuro Oncol
Main Authors: Butowski, Nicholas, Colman, Howard, De Groot, John F., Omuro, Antonio M., Nayak, Lakshmi, Wen, Patrick Y., Cloughesy, Timothy F., Marimuthu, Adhirai, Haidar, Sam, Perry, Arie, Huse, Jason, Phillips, Joanna, West, Brian L., Nolop, Keith B., Hsu, Henry H., Ligon, Keith L., Molinaro, Annette M., Prados, Michael
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2016
Assuntos:
Clinical Investigations
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4799682/
https://ncbi.nlm.nih.gov/pubmed/26449250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nov245
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