Symptomatic and preventive effects of the novel phosphodiesterase-9 inhibitor BI 409306 in an immune-mediated model of neurodevelopmental disorders

BI 409306, a phosphodiesterase-9 inhibitor under development for treatment of schizophrenia and attenuated psychosis syndrome (APS), promotes synaptic plasticity and cognition. Here, we explored the effects of BI 409306 treatment in the polyriboinosinic-polyribocytidilic acid (poly[I:C])-based mouse...

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Detalhes bibliográficos
Publicado no:Neuropsychopharmacology
Main Authors: Scarborough, Joseph, Mattei, Daniele, Dorner-Ciossek, Cornelia, Sand, Michael, Arban, Roberto, Rosenbrock, Holger, Richetto, Juliet, Meyer, Urs
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8209175/
https://ncbi.nlm.nih.gov/pubmed/33941860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41386-021-01016-3
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