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DL0410 ameliorates cognitive disorder in SAMP8 mice by promoting mitochondrial dynamics and the NMDAR-CREB-BDNF pathway
Alzheimer’s disease (AD) is a worldwide problem and there are no effective drugs for AD treatment. Previous studies show that DL0410 is a multi-target, anti-AD agent. In this study, we investigated the therapeutic effect of DL0410 and its action mechanism in SAMP8 mice. DL0410 (1−10 mg·kg(−)(1)·d(−)...
Salvato in:
| Pubblicato in: | Acta Pharmacol Sin |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Springer Singapore
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8209040/ https://ncbi.nlm.nih.gov/pubmed/32868905 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41401-020-00506-2 |
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