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DL0410 ameliorates cognitive deficits in APP/PS1 transgenic mice by promoting synaptic transmission and reducing neuronal loss

At present, few available drugs can be used to either improve pathological features or prevent the progression of Alzheimer’s disease (AD). DL0410 ((1,1′-([1,1′-biphenyl]-4,4′-diyl) bis (3-(piperidin-1-yl) propan-1-one) dihydrochloride) is a multiple-target small molecule that has been found to reve...

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Библиографические подробности
Опубликовано в: :Acta Pharmacol Sin
Главные авторы: Zhou, Wei, Lian, Wen-wen, Yan, Rong, Jia, Hao, Xu, Lv-jie, Wang, Lin, Liu, Ai-lin, Du, Guan-hua
Формат: Artigo
Язык:Inglês
Опубликовано: Springer Singapore 2019
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7471418/
https://ncbi.nlm.nih.gov/pubmed/31685977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41401-019-0312-y
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