DL0410 ameliorates cognitive deficits in APP/PS1 transgenic mice by promoting synaptic transmission and reducing neuronal loss

At present, few available drugs can be used to either improve pathological features or prevent the progression of Alzheimer’s disease (AD). DL0410 ((1,1′-([1,1′-biphenyl]-4,4′-diyl) bis (3-(piperidin-1-yl) propan-1-one) dihydrochloride) is a multiple-target small molecule that has been found to reve...

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Vydáno v:Acta Pharmacol Sin
Hlavní autoři: Zhou, Wei, Lian, Wen-wen, Yan, Rong, Jia, Hao, Xu, Lv-jie, Wang, Lin, Liu, Ai-lin, Du, Guan-hua
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Singapore 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7471418/
https://ncbi.nlm.nih.gov/pubmed/31685977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41401-019-0312-y
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