Reduction of NgR in perforant path decreases amyloid-β peptide production and ameliorates synaptic and cognitive deficits in APP/PS1 mice

BACKGROUND: Amyloid beta (Aβ) which is recognized as a main feature of Alzheimer’s disease (AD) has been proposed to “spread” through anatomically and functionally connected brain regions. The entorhinal cortex and perforant path are the earliest affected brain regions in AD. The perforant path is t...

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Detalhes bibliográficos
Publicado no:Alzheimers Res Ther
Main Authors: Jiang, Rong, Wu, Xue-Fei, Wang, Bin, Guan, Rong-Xiao, Lv, Lang-Man, Li, Ai-Ping, Lei, Lei, Ma, Ye, Li, Na, Li, Qi-Fa, Ma, Quan-Hong, Zhao, Jie, Li, Shao
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7181577/
https://ncbi.nlm.nih.gov/pubmed/32331528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-020-00616-3
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