Reduction of NgR in perforant path decreases amyloid-β peptide production and ameliorates synaptic and cognitive deficits in APP/PS1 mice

BACKGROUND: Amyloid beta (Aβ) which is recognized as a main feature of Alzheimer’s disease (AD) has been proposed to “spread” through anatomically and functionally connected brain regions. The entorhinal cortex and perforant path are the earliest affected brain regions in AD. The perforant path is t...

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Dades bibliogràfiques
Publicat a:Alzheimers Res Ther
Autors principals: Jiang, Rong, Wu, Xue-Fei, Wang, Bin, Guan, Rong-Xiao, Lv, Lang-Man, Li, Ai-Ping, Lei, Lei, Ma, Ye, Li, Na, Li, Qi-Fa, Ma, Quan-Hong, Zhao, Jie, Li, Shao
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2020
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7181577/
https://ncbi.nlm.nih.gov/pubmed/32331528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-020-00616-3
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