Reduction of NgR in perforant path decreases amyloid-β peptide production and ameliorates synaptic and cognitive deficits in APP/PS1 mice

BACKGROUND: Amyloid beta (Aβ) which is recognized as a main feature of Alzheimer’s disease (AD) has been proposed to “spread” through anatomically and functionally connected brain regions. The entorhinal cortex and perforant path are the earliest affected brain regions in AD. The perforant path is t...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Alzheimers Res Ther
Päätekijät: Jiang, Rong, Wu, Xue-Fei, Wang, Bin, Guan, Rong-Xiao, Lv, Lang-Man, Li, Ai-Ping, Lei, Lei, Ma, Ye, Li, Na, Li, Qi-Fa, Ma, Quan-Hong, Zhao, Jie, Li, Shao
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BioMed Central 2020
Aiheet:
Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7181577/
https://ncbi.nlm.nih.gov/pubmed/32331528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-020-00616-3
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