DL0410 Ameliorates Memory and Cognitive Impairments Induced by Scopolamine via Increasing Cholinergic Neurotransmission in Mice

Deficiency of the cholinergic system is thought to play a vital role in cognitive impairment of dementia. DL0410 was discovered as a dual inhibitor of acetylcholinesterase (AChE) and butyrylcholinestease (BuChE), with potent efficiency in in-vitro experiments, but its in vivo effect on the cholinerg...

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Udgivet i:Molecules
Main Authors: Lian, Wenwen, Fang, Jiansong, Xu, Lvjie, Zhou, Wei, Kang, De, Xiong, Wandi, Jia, Hao, Liu, Ai-Lin, Du, Guan-Hua
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6155334/
https://ncbi.nlm.nih.gov/pubmed/28272324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22030410
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