Effects of P-Glycoprotein on the Transport of DL0410, a Potential Multifunctional Anti-Alzheimer Agent

In our study, we attempted to investigate the influences of P-glycoprotein (P-gp) on DL0410, a novel synthetic molecule for Alzheimer’s disease (AD) treatment, for intestinal absorption and blood-brain barrier permeability in vitro and related binding mechanisms in silico. Caco-2, MDCK, and MDCK-MDR...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Pang, Xiaocong, Wang, Lin, Kang, De, Zhao, Ying, Wu, Song, Liu, Ai-Lin, Du, Guan-Hua
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6151990/
https://ncbi.nlm.nih.gov/pubmed/28757552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22081246
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