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Diverse contributions of avidity to the broad neutralization of Dengue virus by antibodies targeting the E dimer epitope

Antibodies (Abs) recognizing the Dengue virus (DENV) E dimer epitope (EDE) that potently neutralize all DENV serotypes are promising templates for vaccine design. As an important feature for some Abs is their bivalency, we sought to define the role avidity plays in neutralization by EDE Abs. We comp...

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Detalhes bibliográficos
Publicado no:Virology
Main Authors: Remmel, Jennifer L, Frei, Julia C, Butler, Savannah E, Lai, Jonathan R, Ackerman, Margaret E
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8205970/
https://ncbi.nlm.nih.gov/pubmed/33819753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2021.03.013
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