Diverse contributions of avidity to the broad neutralization of Dengue virus by antibodies targeting the E dimer epitope

Antibodies (Abs) recognizing the Dengue virus (DENV) E dimer epitope (EDE) that potently neutralize all DENV serotypes are promising templates for vaccine design. As an important feature for some Abs is their bivalency, we sought to define the role avidity plays in neutralization by EDE Abs. We comp...

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Udgivet i:Virology
Main Authors: Remmel, Jennifer L, Frei, Julia C, Butler, Savannah E, Lai, Jonathan R, Ackerman, Margaret E
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8205970/
https://ncbi.nlm.nih.gov/pubmed/33819753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2021.03.013
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