Atg21 organizes Atg8 lipidation at the contact of the vacuole with the phagophore

Coupling of Atg8 to phosphatidylethanolamine is crucial for the expansion of the crescent-shaped phagophore during cargo engulfment. Atg21, a PtdIns3P-binding beta-propeller protein, scaffolds Atg8 and its E3-like complex Atg12–Atg5-Atg16 during lipidation. The crystal structure of Atg21, in complex...

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Dettagli Bibliografici
Pubblicato in:Autophagy
Autori principali: Munzel, Lena, Neumann, Piotr, Otto, Florian B., Krick, Roswitha, Metje-Sprink, Janina, Kroppen, Benjamin, Karedla, Narain, Enderlein, Jörg, Meinecke, Michael, Ficner, Ralf, Thumm, Michael
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2020
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8205015/
https://ncbi.nlm.nih.gov/pubmed/32515645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2020.1766332
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