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Upregulation of brain cholesterol levels inhibits mitophagy in Alzheimer disease

Mitochondrial dysfunction is behind several neurodegenerative diseases, including Alzheimer disease (AD). Accumulation of damaged mitochondria is already observed at the early stages of AD and has been linked to impaired mitophagy, but the mechanisms underlying this alteration are still not fully kn...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Roca-Agujetas, Vicente, de Dios, Cristina, Abadin, Xenia, Colell, Anna
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8204952/
https://ncbi.nlm.nih.gov/pubmed/33945386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2021.1920814
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