Potent SARS-CoV-2 mRNA Cap Methyltransferase Inhibitors by Bioisosteric Replacement of Methionine in SAM Cosubstrate

[Image: see text] Viral mRNA cap methyltransferases (MTases) are emerging targets for the development of broad-spectrum antiviral agents. In this work, we designed potential SARS-CoV-2 MTase Nsp14 and Nsp16 inhibitors by using bioisosteric substitution of the sulfonium and amino acid substructures o...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Bobiļeva, Olga, Bobrovs, Raitis, Kaņepe, Iveta, Patetko, Liene, Kalniņš, Gints, Šišovs, Mihails, Bula, Anna L., Gri̅nberga, Solveiga, Borodušķis, Ma̅rtiņš, Ramata-Stunda, Anna, Rostoks, Nils, Jirgensons, Aigars, Ta̅rs, Kaspars, Jaudzems, Kristaps
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2021
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8204913/
https://ncbi.nlm.nih.gov/pubmed/34257831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.1c00140
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