Loss of all three APP family members during development impairs synaptic function and plasticity, disrupts learning, and causes an autism‐like phenotype

The key role of APP for Alzheimer pathogenesis is well established. However, perinatal lethality of germline knockout mice lacking the entire APP family has so far precluded the analysis of its physiological functions for the developing and adult brain. Here, we generated conditional APP/APLP1/APLP2...

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Publicado en:EMBO J
Main Authors: Steubler, Vicky, Erdinger, Susanne, Back, Michaela K, Ludewig, Susann, Fässler, Dominique, Richter, Max, Han, Kang, Slomianka, Lutz, Amrein, Irmgard, von Engelhardt, Jakob, Wolfer, David P, Korte, Martin, Müller, Ulrike C
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2021
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8204861/
https://ncbi.nlm.nih.gov/pubmed/34008862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020107471
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