Generation of focal mutations and large genomic deletions in the pancreas using inducible in vivo genome editing

Beyond the nearly uniform presence of KRAS mutations, pancreatic cancer is increasingly recognized as a heterogeneous disease. Preclinical in vivo model systems exist, but with the advent of precision oncology, murine models with enhanced genetic flexibility are needed to functionally annotate genet...

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Detalhes bibliográficos
Publicado no:Carcinogenesis
Main Authors: Mishra, Amrendra, Emamgholi, Fatemeh, Erlangga, Zulrahman, Hartleben, Björn, Unger, Kristian, Wolff, Katharina, Teichmann, Ulrike, Kessel, Michael, Woller, Norman, Kühnel, Florian, Dow, Lukas E, Manns, Michael P, Vogel, Arndt, Lowe, Scott W, Saborowski, Anna, Saborowski, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Carcinogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8204487/
https://ncbi.nlm.nih.gov/pubmed/31170286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgz108
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