Generation of focal mutations and large genomic deletions in the pancreas using inducible in vivo genome editing

Beyond the nearly uniform presence of KRAS mutations, pancreatic cancer is increasingly recognized as a heterogeneous disease. Preclinical in vivo model systems exist, but with the advent of precision oncology, murine models with enhanced genetic flexibility are needed to functionally annotate genet...

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Publicado en:Carcinogenesis
Autores principales: Mishra, Amrendra, Emamgholi, Fatemeh, Erlangga, Zulrahman, Hartleben, Björn, Unger, Kristian, Wolff, Katharina, Teichmann, Ulrike, Kessel, Michael, Woller, Norman, Kühnel, Florian, Dow, Lukas E, Manns, Michael P, Vogel, Arndt, Lowe, Scott W, Saborowski, Anna, Saborowski, Michael
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2019
Materias:
Carcinogenesis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8204487/
https://ncbi.nlm.nih.gov/pubmed/31170286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgz108
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