Generation of focal mutations and large genomic deletions in the pancreas using inducible in vivo genome editing

Beyond the nearly uniform presence of KRAS mutations, pancreatic cancer is increasingly recognized as a heterogeneous disease. Preclinical in vivo model systems exist, but with the advent of precision oncology, murine models with enhanced genetic flexibility are needed to functionally annotate genet...

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Dades bibliogràfiques
Publicat a:Carcinogenesis
Autors principals: Mishra, Amrendra, Emamgholi, Fatemeh, Erlangga, Zulrahman, Hartleben, Björn, Unger, Kristian, Wolff, Katharina, Teichmann, Ulrike, Kessel, Michael, Woller, Norman, Kühnel, Florian, Dow, Lukas E, Manns, Michael P, Vogel, Arndt, Lowe, Scott W, Saborowski, Anna, Saborowski, Michael
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
Matèries:
Carcinogenesis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8204487/
https://ncbi.nlm.nih.gov/pubmed/31170286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgz108
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