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Structural basis for recruitment of the CHK1 DNA damage kinase by the CLASPIN scaffold protein
CHK1 is a protein kinase that functions downstream of activated ATR to phosphorylate multiple targets as part of intra-S and G2/M DNA damage checkpoints. Its role in allowing cells to survive replicative stress has made it an important target for anti-cancer drug discovery. Activation of CHK1 by ATR...
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| Pubblicato in: | Structure |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Cell Press
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8204404/ https://ncbi.nlm.nih.gov/pubmed/33789090 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2021.03.007 |
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