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Substrate binding in the multidrug transporter MdfA in detergent solution and in lipid nanodiscs

MdfA from Escherichia coli is a prototypical secondary multi-drug (Mdr) transporter that exchanges drugs for protons. MdfA-mediated drug efflux is driven by the proton gradient and enabled by conformational changes that accompany the recruitment of drugs and their release. In this work, we applied d...

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Détails bibliographiques
Publié dans:Biophys J
Auteurs principaux: Bahrenberg, Thorsten, Yardeni, Eliane Hadas, Feintuch, Akiva, Bibi, Eitan, Goldfarb, Daniella
Format: Artigo
Langue:Inglês
Publié: The Biophysical Society 2021
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8204392/
https://ncbi.nlm.nih.gov/pubmed/33771471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2021.03.014
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