Attenuated strain of CVB3 with a mutation in the CAR-interacting region protects against both myocarditis and pancreatitis

Coxsackievirus B3 (CVB3), is commonly implicated in myocarditis, which can lead to dilated cardiomyopathy, in addition to causing acute pancreatitis and meningitis. Yet, no vaccines are currently available to prevent this infection. Here, we describe the derivation of a live attenuated vaccine virus...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Lasrado, Ninaad, Gangaplara, Arunakumar, Massilamany, Chandirasegaran, Arumugam, Rajkumar, Shelbourn, Allison, Rasquinha, Mahima T., Basavalingappa, Rakesh H., Delhon, Gustavo, Xiang, Shi-Hua, Pattnaik, Asit K., Steffen, David, Reddy, Jay
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8203608/
https://ncbi.nlm.nih.gov/pubmed/34127684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-90434-w
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