IL-23 reshapes kidney resident cell metabolism and promotes local kidney inflammation

Interstitial kidney inflammation is present in various nephritides in which serum interleukin 23 (IL-23) is elevated. Here we showed that murine and human renal tubular epithelial cells (TECs) expressing the IL-23 receptor (IL-23R) responded to IL-23 by inducing intracellular calcium flux, enhancing...

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Bibliografske podrobnosti
izdano v:J Clin Invest
Main Authors: Li, Hao, Tsokos, Maria G., Bhargava, Rhea, Adamopoulos, Iannis E., Menn-Josephy, Hanni, Stillman, Isaac E., Rosenstiel, Philip, Jordan, Jarrat, Tsokos, George C.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2021
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8203450/
https://ncbi.nlm.nih.gov/pubmed/33956666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI142428
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