The insulin receptor family and protein kinase B (Akt) are activated in the heart by alkaline pH and α(1)-adrenergic receptors

Insulin and insulin-like growth factor stimulate protein synthesis and cardioprotection in the heart, acting through their receptors (INSRs, IGF1Rs) and signalling via protein kinase B (PKB, also known as Akt). Protein synthesis is increased in hearts perfused at alkaline pH(o) to the same extent as...

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Veröffentlicht in:Biochem J
Hauptverfasser: Meijles, Daniel N., Fuller, Stephen J., Cull, Joshua J., Alharbi, Hajed O., Cooper, Susanna T.E., Sugden, Peter H., Clerk, Angela
Format: Artigo
Sprache:Inglês
Veröffentlicht: Portland Press Ltd. 2021
Schlagworte:
Cardiovascular System & Vascular Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8203208/
https://ncbi.nlm.nih.gov/pubmed/34002209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20210144
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