MAP4K4 expression in cardiomyocytes: multiple isoforms, multiple phosphorylations and interactions with striatins

The Ser/Thr kinase MAP4K4, like other GCKIV kinases, has N-terminal kinase and C-terminal citron homology (CNH) domains. MAP4K4 can activate c-Jun N-terminal kinases (JNKs), and studies in the heart suggest it links oxidative stress to JNKs and heart failure. In other systems, MAP4K4 is regulated in...

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Udgivet i:Biochem J
Main Authors: Fuller, Stephen J., Edmunds, Nick S., McGuffin, Liam J., Hardyman, Michelle A., Cull, Joshua J., Alharbi, Hajed O., Meijles, Daniel N., Sugden, Peter H., Clerk, Angela
Format: Artigo
Sprog:Inglês
Udgivet: Portland Press Ltd. 2021
Fag:
Cardiovascular System & Vascular Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8203206/
https://ncbi.nlm.nih.gov/pubmed/34032269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20210003
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