Extracellular Superoxide Dismutase (EC-SOD) Regulates Gene Methylation and Cardiac Fibrosis During Chronic Hypoxic Stress

Chronic hypoxic stress induces epigenetic modifications mainly DNA methylation in cardiac fibroblasts, inactivating tumor suppressor genes (RASSF1A) and activating kinases (ERK1/2) leading to fibroblast proliferation and cardiac fibrosis. The Ras/ERK signaling pathway is an intracellular signal tran...

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Dades bibliogràfiques
Publicat a:Front Cardiovasc Med
Autors principals: Rajgarhia, Ayan, Ayasolla, Kameshwar R., Zaghloul, Nahla, Lopez Da Re, Jorge M., Miller, Edmund J., Ahmed, Mohamed
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2021
Matèries:
Cardiovascular Medicine
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8202000/
https://ncbi.nlm.nih.gov/pubmed/34136546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcvm.2021.669975
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