Extracellular Superoxide Dismutase (EC-SOD) Regulates Gene Methylation and Cardiac Fibrosis During Chronic Hypoxic Stress

Chronic hypoxic stress induces epigenetic modifications mainly DNA methylation in cardiac fibroblasts, inactivating tumor suppressor genes (RASSF1A) and activating kinases (ERK1/2) leading to fibroblast proliferation and cardiac fibrosis. The Ras/ERK signaling pathway is an intracellular signal tran...

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Detaylı Bibliyografya
Yayımlandı:Front Cardiovasc Med
Asıl Yazarlar: Rajgarhia, Ayan, Ayasolla, Kameshwar R., Zaghloul, Nahla, Lopez Da Re, Jorge M., Miller, Edmund J., Ahmed, Mohamed
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2021
Konular:
Cardiovascular Medicine
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8202000/
https://ncbi.nlm.nih.gov/pubmed/34136546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcvm.2021.669975
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