Extracellular Superoxide Dismutase (EC-SOD) Regulates Gene Methylation and Cardiac Fibrosis During Chronic Hypoxic Stress

Chronic hypoxic stress induces epigenetic modifications mainly DNA methylation in cardiac fibroblasts, inactivating tumor suppressor genes (RASSF1A) and activating kinases (ERK1/2) leading to fibroblast proliferation and cardiac fibrosis. The Ras/ERK signaling pathway is an intracellular signal tran...

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Bibliografiske detaljer
Udgivet i:Front Cardiovasc Med
Main Authors: Rajgarhia, Ayan, Ayasolla, Kameshwar R., Zaghloul, Nahla, Lopez Da Re, Jorge M., Miller, Edmund J., Ahmed, Mohamed
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Cardiovascular Medicine
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8202000/
https://ncbi.nlm.nih.gov/pubmed/34136546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcvm.2021.669975
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