Extracellular Superoxide Dismutase (EC-SOD) Regulates Gene Methylation and Cardiac Fibrosis During Chronic Hypoxic Stress

Chronic hypoxic stress induces epigenetic modifications mainly DNA methylation in cardiac fibroblasts, inactivating tumor suppressor genes (RASSF1A) and activating kinases (ERK1/2) leading to fibroblast proliferation and cardiac fibrosis. The Ras/ERK signaling pathway is an intracellular signal tran...

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Bibliografski detalji
Izdano u:Front Cardiovasc Med
Glavni autori: Rajgarhia, Ayan, Ayasolla, Kameshwar R., Zaghloul, Nahla, Lopez Da Re, Jorge M., Miller, Edmund J., Ahmed, Mohamed
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2021
Teme:
Cardiovascular Medicine
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8202000/
https://ncbi.nlm.nih.gov/pubmed/34136546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcvm.2021.669975
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