Extracellular Superoxide Dismutase (EC-SOD) Regulates Gene Methylation and Cardiac Fibrosis During Chronic Hypoxic Stress

Chronic hypoxic stress induces epigenetic modifications mainly DNA methylation in cardiac fibroblasts, inactivating tumor suppressor genes (RASSF1A) and activating kinases (ERK1/2) leading to fibroblast proliferation and cardiac fibrosis. The Ras/ERK signaling pathway is an intracellular signal tran...

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Bibliographic Details
Published in:Front Cardiovasc Med
Main Authors: Rajgarhia, Ayan, Ayasolla, Kameshwar R., Zaghloul, Nahla, Lopez Da Re, Jorge M., Miller, Edmund J., Ahmed, Mohamed
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2021
Subjects:
Cardiovascular Medicine
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8202000/
https://ncbi.nlm.nih.gov/pubmed/34136546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcvm.2021.669975
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