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Structures suggest an approach for converting weak self-peptide tumor antigens into superagonists for CD8 T cells in cancer
Tumors frequently express unmutated self-tumor–associated antigens (self-TAAs). However, trial results using self-TAAs as vaccine targets against cancer are mixed, often attributed to deletion of T cells with high-affinity receptors (TCRs) for self-TAAs during T cell development. Mutating these weak...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2021
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8201969/ https://ncbi.nlm.nih.gov/pubmed/34074778 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2100588118 |
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