Structures suggest an approach for converting weak self-peptide tumor antigens into superagonists for CD8 T cells in cancer

Tumors frequently express unmutated self-tumor–associated antigens (self-TAAs). However, trial results using self-TAAs as vaccine targets against cancer are mixed, often attributed to deletion of T cells with high-affinity receptors (TCRs) for self-TAAs during T cell development. Mutating these weak...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Wei, Pengcheng, Jordan, Kimberly R., Buhrman, Jonathan D., Lei, Jun, Deng, Hexiang, Marrack, Philippa, Dai, Shaodong, Kappler, John W., Slansky, Jill E., Yin, Lei
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8201969/
https://ncbi.nlm.nih.gov/pubmed/34074778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2100588118
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